A multi-array multi-SNP genotyping algorithm for Affymetrix SNP microarrays
نویسندگان
چکیده
منابع مشابه
A multi-array multi-SNP genotyping algorithm for Affymetrix SNP microarrays
MOTIVATION Modern strategies for mapping disease loci require efficient genotyping of a large number of known polymorphic sites in the genome. The sensitive and high-throughput nature of hybridization-based DNA microarray technology provides an ideal platform for such an application by interrogating up to hundreds of thousands of single nucleotide polymorphisms (SNPs) in a single assay. Similar...
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In this paper we develop a new method for genotyping Affymetrix single nucleotide polymorphism (SNP) array. The method is based on (i) using multiple arrays at the same time to determine the genotypes and (ii) a model that relates intensities of individual SNPs to each other. The latter point allows us to annotate SNPs that have poor performance, either because of poor experimental conditions o...
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Figure S1 (Related to Figure 1). A. Genome graph showing distribution of SNPs across the genome. B. Estimated marker informativeness for an F2 intercross between wild caught sticklebacks. C. Histogram showing the distribution of average pairwise FST between global populations. Figure S2 (Related to Figure 3). A self dot-plot showing sequence similarity of a 390kb region on chromosome X with two...
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MOTIVATION A classification algorithm, based on a multi-chip, multi-SNP approach is proposed for Affymetrix SNP arrays. Current procedures for calling genotypes on SNP arrays process all the features associated with one chip and one SNP at a time. Using a large training sample where the genotype labels are known, we develop a supervised learning algorithm to obtain more accurate classification ...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2007
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btm131